322 BCE - 275 BCE: The Wars of the Diadochi, also known as the Wars of Alexander's Successors.

321 BCE - 315 BCE: Seleucos rules the satrapy of Babylon.

312 BCE: Demetrius I of Macedon loses the Battle of Giza against Ptolemy I and Seleucus I Nicator.

312 BCE: Evagros is killed in battle by Seleucos I. Persis comes under Seleucid rule.

312 BCE: Seleucos conquers Babylon and founds the Seleucid dynasty.

305 BCE: Emperor Chandragupta signs a treaty with Seleucos I, establishing borders and giving the Punjab to Chandragupta in return for 500 war elephants.

304 BCE: Seleucos I refounds and renames the ancient city thereafter known as Edessa.

301 BCE: Battle of Ipsos. Death of Antigonos, rise to power of Lysimachus and Seleucus.

301 BCE - 299 BCE: Antioch founded by Seleucos I Nicator.

299 BCE: Demetrius I marries Stratonice, daughter of Seleucus I and in return Demetrius is given Cilicia.

295 BCE: Seleucos I makes an alliance with local Persis dynast, Ardaxsir, becoming the first frataraka of Persis.

293 BCE: Antiochos is appointed vice-king of the Upper-Satrapies by his father Seleucus I Nicator.

285 BCE: Demetrius I surrenders to Seleucus I and lives as a prsioner for three years until his death.